In the present study, mesoporous magnesium silicate (m-MS) was synthesized via non-ionic surfactant-assisted sol-gel method. The m-MS was produced into an acidic medium and calcined at 550 º C temperature to remove the organic template (P123). The aim of this study was to evaluate the ability and application of drug loading and controlled release from m-MS. In addition, the effect of drug loading and release on textural properties of m-MS such as surface area, pore diameter and pore volume was investigated. The synthesized compound was studied by X-ray diffraction (XRD), Fourier transform infrared spectra (FTIR), Brunauer– Emmett– Teller (BET) surface area analysis, transmission electron microscopy (TEM) and Uv-vis spectrophotometer. The low angle XRD, BET and TEM results showed that magnesium silicate contained 2D hexagonal honeycomb pore channels with uniform and homogeneously distributed mesopores of the same size. The m-MS demonstrated large specific surface area by about 504 m2/g and after adsorption of ibuprofen, the N2 adsorbed volume decreased obviously, and the corresponding BET surface area, pore size and pore volume changed from the 504 m2/g, 4. 6 nm, 0. 44 cc/g (550 º C) to 225 m2/g, 1. 2 nm, 0. 21 cc/g (550 º C drug loaded) respectively. This study revealed that m-MS has the ability to drug loading and controlled release of ibuprofen and can be used as a novel drug delivery system.

Purpose: The main aim of the present study was to design, fabrication and physicochemical characteristics of the magnetogel nanospheres as carriers for Cisplatin in the in vitro environment. Methods: Magnetic nanospheres were synthesized by using a chemical co-precipitation method and coated by sodium alginate through double emulsion method. Then cisplatin was encapsulated into β-cyclodextrin-sodium alginate grafted magnetic nanospheres. The physicochemical properties of the sodium alginate grafted magnetic nanospheres were characterized by using FTIR, particle size analyzing, vibrating sample magnetometry, thermogravimetric and SEM analysis. Also the drug entrapment efficiency, content and in vitro release profile were investigated. Results: Size distribution results revealed that the particles size was distributed in the range of 50± nm. Also morphological properties showed that particles are separated and spherical with the grafted layers of the polymer. The release profile data were in the acceptable range compared to the blank (cisplatin solution). Conclusion: It could be concluded that the sodium alginate grafted magnetic nanospheres could act as a slow and controlled release system to deliver cisplatin.

Silk fibroin (SF) as an important natural polymer has been extensively used as a suitable matrix in controlled drug release systems because of its biocompatibility feature, slow degradation rate and unique mechanical properties. In this study, a new b-cyclodextrin/silk fibroin nano fibrous membrane (b-CD/SF) with the function of molecular capture was successfully prepared by electro spinning of homogeneous solutions of b-CD and SF in formic acid. The effects of cyclodextrin on the nano fibers properties and its drug release properties were investigated. The morphology, microscopic structure, chemical composition and heat treatment of the b-CD/SF nano fibrous membrane were characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). Scanning electronic microscopy images showed that defect free mats with a uniform structure were generated, and the average diameter of the nano fibers was mainly affected by weight ratio of the blend. The result revealed that increasing the β-CD content in the blends lowered the average fiber diameter. In this report these observations are discussed with respect to the viscosity data of the electro spinning solutions which have been decreased with increasing b-cyclodextrin concentration. Differential scanning calorimetry results showed that drug was loaded into the b-cyclodextrin cavities. In vitro drug delivery profile of salicylic acid, as a drug model, was examined by UV spectroscopy at body temperature (37˚C) in phosphate buffer saline (pH 7.4). The molecular capturing ability of b-cyclodextrin/silk fibroin composite was improved with the amount of b-cyclodextrin in composite nano fibrous membrane which resulted in lower drug release.